I was working on a few days ago when Radiance of the Seas and Celebrity Millennium sailed from Vancouver to sea. They dropped the Pilots off Victoria at 22:15. They rounded "J"bouy (where they are permitted to turn sound past Cape Flattery) at 03:00. Their speed was only 18 knots, so your voyage will be much the same.
I recently traveled on the Crown Princess on a Mexican Riviera cruise (as per my photos), and the cruise went off without a hitch, aside from two minor incidents:
1) My mother's luggage was lost at the ever dumpy airport in Los Angeles, and as it turns out, was taken by mistake by a patron of our very cruise. We were able to rescue it on day 2, but not without first developing a stock of contingency clothing from Target. Huge props to Guest Services on board for getting that sorted out.
2) There was a noro-virus outbreak on board the ship that started from pretty much Day 1 onward. While none of our 12 person party ever contracted it, the ship was indeed on sanitation lock-down for the entire duration of the trip. Really motivates you to consider what you touch and think of where your food comes from.